Prevention, diagnosis and treatment of tumor lysis syndrome

Tumor lysis syndrome (TLS) is an acute, life-threatening condition that occurs either spontaneously or as a complication of cytoreductive antitumor therapy, and in both children adults. As result TLS, intracellular components are released into the extracellular space, leading to dysregulation body's homeostasis due accumulation uric acid, phosphate potassium ions, hypocalcemia, which may lead cardiac arrhythmias, convulsions, kidney failure.